Chelation therapy involves the intravenous administration of ethylenediaminetetraacetic acid (EDTA). EDTA enters the bloodstream and binds heavy metals such as lead, mercury, iron, and cadmium. By carrying these heavy metals out of the body through the urine, EDTA reduces the body’s toxic metal burden, gently restoring elasticity and flow to the blood vessels. This intravenous treatment has been safely used for the past 60 years, and has been administered to over a million patients.

Conditions Regularly Treated:

  • Heavy Metal Detoxification

Sampling of Clinical Research

L. Terry Chappell, M.D. Applications Of EDTA Chelation Therapy. Alt Med Rev 1997;2(6):426-432.

Blumer W, Cranton EM. Ninety percent reduction in cancer mortality after chelation therapy with EDTA. J Adv Med 1989;2:183- Bjorksten J. Possibilities and limitations of chelation as a means for life extension. J Adv Med 1989;2:77-78.

Cranton EM. Kidney effects of ethylene diamine tetra acetic acid (EDTA): a literature review. J Adv Med 1989;2:227-234.

Weismann K: Neurosyphilis, or chronic heavy metal poisoning: Karen Blixen's lifelong disease. Sex Transm Dis 1995, 22:137-144.

Flora SJS, Mittal M, Metha A: Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med. Res 2008, 128:501-523.

Clarkson TW, Vyas JB, Ballatori N: Mechanisms of mercury disposition in the body. Am J Ind Med 2007, 50:757-764. Blanusa M, Varnai VM, Piasek M, Kostial K: Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem 2005, 12:2771-2794.

Tantanasrikul S, Chaivisuth B, Siriratanapreuk S, Padungtod C, Pleubreukan R, Boonnark T, Worahan S, Bhumiratanarak P, Chomchai C: The management of environmental lead exposure in the pediatric population: lessons from Clitty Creek, Thailand. J Med Assoc Thai 2002, 85(Suppl 2):S762-768.

Mycyk MB, Leikin JB: Combined exchange transfusion and chelation therapy for neonatal lead poisoning. Ann Pharmacother 2004, 38:821-824.

Lin-Tan DT, Lin JL, Yen TH, Chen KH, Huang YL: Long-term outcome of repeated lead chelation therapy in progressive nondiabetic chronic kidney diseases. Nephrol Dial Transplant 2007, 22:2924-2931.

Foglieni C, Fulgenzi A, Ticozzi P, Pellegatta F, Sciorati C, Belloni D, Ferrero E, Ferrero ME: Protective effect of EDTA preadministration on renal ischemia. BMC Nephrol 2006, 7:5-16.

Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis. 1998;141:1–15.

Folcik VA, Nivar-Aristy RA, Krajewski LP, Cathcart MK. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. J Clin Invest. 1995;96:504–510.

Leeuwenburgh C, Hardy MM, Hazen SL, Wagner P, Oh-ishi S, Steinbrecher UP, Heinecke JW. Reactive nitrogen intermediates promote low-density lipoprotein oxidation in human atherosclerotic intima. J Biol Chem. 1997;272:1433–1436.
Jick S, Karsh R. The effect of calcium chelation on cardiac arrhythmias and conduction disturbances. Am J Card 1959:287-293.

Leipzig LJ, Boyle AJ, McCann DS. Case histories of rheumatoid arthritis treated with sodium or magnesium EDTA. J Chron Dis1970;22:553-563.

Bark RE. Treatment of systemic sclerosis. Mod Treat 1966;3:1287-1301.

McDonagh EW, Rudolph CJ, Cheraskin E. The effect of EDTA chelation therapy with multivitamin/trace mineral supplementation upon reported fatigue. J Orthomol Psych 1983;13:1-54.

McDonagh EW, Rudolph CJ, Wussow DG. The effect of intravenous disodium ethylene diamine tetraacetic acid (EDTA) upon bone density levels. J Adv Med 1988;1:79-85.

McDonagh EW, Rudolph CJ, Barber RK. Effect of EDTA chelation and supportive multivitamin mineral supplementation on chronic lung disorders: A study of FVC and FEV1. J Adv Med 1989;2:553-561.

Blumer W, Reich T. Drug dependence caused by toxic metals, Metal Compounds in Environment and Life 1992;4:231-236.


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